Multidisciplinary Cardiovascular Annals

Published by: Kowsar

Impact of Different Prophylactic Antibiotic Regimen on Clinical Outcome of Coronary Artery Bypass Graft Surgery

Farzaneh Shirnia 1 , Naser Hadavand 2 , Maryam Mirzaei 3 , Nicholas Austine 4 , Hooman Bakhshandeh 5 , Hassan Mirmohammadsadeghi 5 and Alireza Alizadeh Ghavidel 5 , *
Authors Information
1 ICU Registered Nurse, Imam Hossein Hospital, Hashtroud, East Azerbaijan, IR Iran
2 Assistant Professor of Clinical Pharmacy, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
3 ICU Registered Nurse, Jahrom University of Medical Sciences, Jahrom, IR Iran
4 Medical Student, Iran University of Medical Sciences, Tehran, IR Iran
5 Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
Article information
  • Multidisciplinary Cardiovascular Annals: January 2018, 9 (1); e65154
  • Published Online: June 27, 2017
  • Article Type: Research Article
  • Received: April 14, 2017
  • Revised: May 19, 2017
  • Accepted: June 19, 2017
  • DOI: 10.5812/mcardia.65154

To Cite: Shirnia F, Hadavand N, Mirzaei M, Austine N, Bakhshandeh H, et al. Impact of Different Prophylactic Antibiotic Regimen on Clinical Outcome of Coronary Artery Bypass Graft Surgery, Multidiscip Cardio Annal. 2018 ; 9(1):e65154. doi: 10.5812/mcardia.65154.

Copyright © 2017, Multidisciplinary Cardiovascular Annals. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Bailly P, Lallemand S, Thouverez M, Talon D. Multicentre study on the appropriateness of surgical antibiotic prophylaxis. J Hosp Infect. 2001;49(2):135-8. doi: 10.1053/jhin.2001.1064. [PubMed: 11567560].
  • 2. Bratzler DW, Houck PM.Surgical Infection Prevention Guidelines Writers Workgroup; American Academy of Orthopaedic Surgeons; merican Association of Critical Care Nurses; American Association of Nurse Anesthetists; et al. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis. 2004;38(12):1706-15. doi: 10.1086/421095. [PubMed: 15227616].
  • 3. Kappeler R, Gillham M, Brown NM. Antibiotic prophylaxis for cardiac surgery. J Antimicrob Chemother. 2012;67(3):521-2. doi: 10.1093/jac/dkr536. [PubMed: 22186878].
  • 4. De Jonge SW, Gans SL, Atema JJ, Solomkin JS, Dellinger PE, Boermeester MA. Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(29). e6903. doi: 10.1097/MD.0000000000006903. [PubMed: 28723736].
  • 5. Pitt HA, Postier RG, MacGowan AW, Frank LW, Surmak AJ, Sitzman JV, et al. Prophylactic antibiotics in vascular surgery. Topical, systemic, or both? Ann Surg. 1980;192(3):356-64. [PubMed: 6998390].
  • 6. Young PY, Khadaroo RG. Surgical site infections. Surg Clin North Am. 2014;94(6):1245-64. doi: 10.1016/j.suc.2014.08.008. [PubMed: 25440122].
  • 7. Finkelstein R, Rabino G, Mashiah T, Bar-El Y, Adler Z, Kertzman V, et al. Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections. J Thorac Cardiovasc Surg. 2002;123(2):326-32. [PubMed: 11828293].
  • 8. Bhatia JY, Pandey K, Rodrigues C, Mehta A, Joshi VR. Postoperative wound infection in patients undergoing coronary artery bypass graft surgery: a prospective study with evaluation of risk factors. Indian J Med Microbiol. 2003;21(4):246-51. [PubMed: 17643036].
  • 9. Sinha L, Yunus A, Hussain S. Antibiotic Prophylaxis for Preventing Surgical Site Infection after Coronary Artery Bypass Graft: Prospective Randomized Comparative Study. Mortality.
  • 10. Friberg O, Svedjeholm R, Soderquist B, Granfeldt H, Vikerfors T, Kallman J. Local gentamicin reduces sternal wound infections after cardiac surgery: a randomized controlled trial. Ann Thorac Surg. 2005;79(1):153-61. discussion 161-2. doi: 10.1016/j.athoracsur.2004.06.043. [PubMed: 15620935].
  • 11. Harbarth S, Samore MH, Lichtenberg D, Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation. 2000;101(25):2916-21. [PubMed: 10869263].
  • 12. Edwards FH, Engelman RM, Houck P, Shahian DM, Bridges CR, Society of Thoracic S. The Society of Thoracic Surgeons Practice Guideline Series: Antibiotic Prophylaxis in Cardiac Surgery, Part I: Duration. Ann Thorac Surg. 2006;81(1):397-404. doi: 10.1016/j.athoracsur.2005.06.034. [PubMed: 16368422].
  • 13. Eagle KA, Guyton RA, Davidoff R, Edwards FH, Ewy GA, Gardner TJ, et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery). J Am Coll Cardiol. 2004;44(5):e213-310. doi: 10.1016/j.jacc.2004.07.021. [PubMed: 15337239].

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