Cryoablative Cox Maze Procedure and Pulmonary Vein Isolation for Treatment of Atrial Fibrillation in Rheumatic Heart Disease Undergoing Mitral Valve Surgery

AUTHORS

Bahram Ghasemzadeh 1 , Shayan Naghshbandi 2 , Yousef Rezaei 2 , * , Masoud Shafiei 2 , Bahareh Kazemborji 2 , Majid Haghjoo 3 , Tooraj Babaei 4 , Majid Maleki 5 , Saeid Hosseini 2

1 Department of Cardiac Surgery, Shiraz University of Medical Sciences, Shiraz, IR Iran

2 Heart Valve Disease Research Center , Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

3 Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

4 Department of Cardiac Anesthesiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

5 Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran

How to Cite: Ghasemzadeh B, Naghshbandi S, Rezaei Y, Shafiei M, Kazemborji B, et al. Cryoablative Cox Maze Procedure and Pulmonary Vein Isolation for Treatment of Atrial Fibrillation in Rheumatic Heart Disease Undergoing Mitral Valve Surgery, Multidiscip Cardio Annal. 2016 ; 7(1):e9178. doi: 10.17795/mcardia.9178.

ARTICLE INFORMATION

Multidisciplinary Cardiovascular Annals: 7 (1); e9178
Published Online: September 27, 2016
Article Type: Research Article
Received: August 3, 2016
Revised: August 22, 2016
Accepted: September 21, 2016
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Abstract

Introduction: The cox-maze procedure (CMP) is considered the gold standard surgical therapy for atrial fibrillation (AF), however, cryosurgical ablations are changing daily practice. The aim of this study was to assess the safety and efficacy of the cryosurgical ablation in rheumatic mitral valve (MV) patients with chronic AF undergoing MV surgery with or without concomitant cardiac surgeries and to compare cryoablative CMP with surgical cryoablative pulmonary vein isolation (cryo-PVI).

Methods: In a prospective observational study, a total of 65 patients with long-standing persistent AF who had MV surgeries as the main procedure and underwent either biatrial cryoablative CMP-IV or surgical cryo-PVI were evaluated.

Results: The patients’ mean age was 49.6 ± 10.6 years, and they were followed for a median of 16 months (ranging from 3 to 60 months). The rates of sinus rhythm were 60.9% in the CMP-IV and 74.3% in the surgical cryo-PVI groups at follow-up period. The preoperative LA size of > 4.5 cm discriminated late AF with a sensitivity of 89% and a specificity of 45% (area under receiver operating characteristics curve = 0.733, 95% confidence interval [CI] = 0.602 - 0.863). No in-hospital mortality and permanent pace-maker implantation were developed. In Cox regression analysis, the preoperative LA size (Hazard ratio [HR] 1.962, 95% CI 1.175 - 3.276, P = 0.010) and AF duration (HR 1.028, 95% CI 1.002 - 1.054, P = 0.032) predicted late AF.

Conclusions: Cryoablative CMP-IV or surgical cryo-PVI for long-standing persistent AF are safe, efficacious, and cost-effective at restoring sinus rhythm in the setting of rheumatic MV surgery combined with or without other cardiac surgeries.

Keywords

Atrial Fibrillation Mitral Valve Surgery Cox Maze Procedure Pulmonary Vein Isolation Left Atrial Size

Copyright © 2016, Iranian Society of Cardiac Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

1. Introduction

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with a high prevalence increasing with ageing. In patients undergoing cardiac surgery, AF has been associated with enhanced perioperative complications and worse late survival (1). AF presents in approximately 60% - 80% of patients undergoing mitral valve (MV) surgery. Pharmacological management for AF has been associated with some limitations and a low success rate about 50% of cases (2), leading to the development of interventional procedures, including catheter ablation and surgeries (3).

The Cox-Maze procedure (CMP) is the gold standard procedure used in the surgical treatment of AF (4). On the other hand, experimental and clinical studies have consistently shown that focal discharges from the pulmonary veins are implicated in the initiation and perpetuation of AF (5). Therefore, this finding opened the door for catheter ablation of AF and pulmonary vein isolation (PVI) (6, 7). The CMP-III is accompanied by technical complexity and invasiveness; hence, it is replaced by a simplified procedure involving ablation lines, named CMP-IV (8). The latter provides surgeons with the option to implement a combination of bipolar radiofrequency (RF) ablation or cryoablation (9).

Rheumatic heart disease (RHD) is the most common cause of AF in developing countries and more than 80% of preoperative chronic AF remains after valvular surgery alone (4). The major cardiac and surgical societies have recommended that concomitant surgical approaches for AF should be performed in all cases when feasible (10). Herein, we aimed to evaluate the clinical outcomes of the N2O-based surgical cryo-PVI in RHD patients with long-standing persistent AF undergoing MV surgeries with or without concomitant surgeries and to compare these findings with those of the biatrial cryoablative CMP-IV.

2. Methods

2.1. Study Protocol and Population

In a prospective observational study from February 2010 to November 2012, a total of 65 consecutive patients with rheumatic MV disease associated with long-standing persistent AF, defined as AF lasting more than 6 months who were scheduled to undergo MV replacement (MVR) or MV repair with or without additional cardiac operations, were enrolled into the study. The cryoablative operation was performed either as biatrial CMP-IV in 25 patients (CMP-IV group) or as surgical cryo-PVI in 40 patients (PVI group). This study was approved by the local ethics committee in Rajaie cardiovascular medical and research center and written informed consents were also obtained from the patients.

2.2. Surgical Techniques

All procedures were performed by a single surgeon. The biatrial CMP-IV was performed with a wide-angled cryoprobe (Danesh® Medical Engineering Co., Tehran, Iran). The N2O-based cryoablation device is a newly designed tool that is approved by the Iran ministry of health; therefore, the patients were informed. The probes were cooled down at least to -60°C. In order to have a maximum tissue penetration during cryoablation, 2 minutes of tissue contact was implemented.

All patients had long-standing RHD with persistent AF. The MV operations were done after the induction of general anesthesia through a classic midline sternotomy. Cardiopulmonary bypass was then established using ascending aorta and bicaval cannulations associated with applying moderate hypothermia (32°C). They underwent preoperative transesophageal echocardiography to confirm the absence of left atrial (LA) thrombus. In some cases, concomitant procedures including coronary artery bypass grafting or other valvular surgery were also carried out. All patients underwent closure of the left atrial appendage (LAA) to reduce the risks of stroke as well. In the PVI group, the cryosurgical ablation was performed as follows: 1) LA atriotomy incision was applied; 2) MV was evaluated for implementing either MVR or MV repair; 3) In the cases of MVR, MV was excised and then cryosurgical ablation performed and consequently a suitably sized prosthetic valve was replaced; 4) in the cases of MV repair, first the cryosurgical ablation was done and then MV was repaired. The cryoablative lines were drawn to encompass the PVs and an additional ablation line was drawn from the left surgical atriotomy to the posterior MV annulus (Figure 1). In the CMP-IV group, in addition to the above-mentioned lines, other right atrial and atrial septum cryoablation lines were applied as follows: 1) Right atrial (RA) appendage was excised and right atriotomy extended up to the mid part of the RA; 2) a line was placed on atrial septum; 3) a line was made between superior and inferior vena cavas; 4) a line was made from the excised RA appendage to the annulus of tricuspid valve (TV) away from atrioventricular conduction system; 5) after creating a small hole in anterior part of the RA adjacent to the posterior leaflet of TV, two other lines were made, including a line from the hole to the middle part of the first line between vena cavas and another extending from the hole to the TV annulus. Moreover, intraoperative transesophageal echocardiography was done for all patients. Two right ventricular and two RA epicardial pacing wires were placed in all patients for dual-chamber pacing when needed. There was no preference for selecting the ablation procedures in our cohort. After surgery, all patients received heparin continued by warfarin to reach an international normalized ratio (INR) of 2.5-3.5, and then went on warfarin regimen alone. No electrical or medical cardioversion were applied postoperatively to restore sinus rhythm.

Blue Pathways Showing Cryoablation Lines During Surgical Cryo-PVI
Figure 1. Blue Pathways Showing Cryoablation Lines During Surgical Cryo-PVI

2.3. Follow-Up

The patients’ follow-up assessment was applied in three time intervals, including in-hospital, 1-month, and late periods. After surgery, antiarrhythmic drugs were continued using propranolol (20 - 80 mg/day) or metoproterenol (25 - 100 mg/day). At each follow-up interval, the patients underwent physical examination, electrocardiogram evaluation, and Holter monitoring in patients with normal sinus rhythm. Echocardiographic evaluations were performed at each follow-up except for the late follow-up at which echocardiography was performed in patients with suspicion of prosthetic valve dysfunction.

2.4. Statistical Analysis

Continuous variables were reported as mean ± standard deviation or median (interquartile ranges); those were analyzed using t-test or Mann-Whitney U test as appropriate. Categorical variables were reported as number (percentage) and Chi-square test or Fisher Exact tests were used as appropriate. Receiver operating characteristic (ROC) curve was used for identifying the best cut-off point for LA size to detect the patients with AF at late follow-up. The Cox regression analysis was also conducted to identify the main predictors of late AF during follow-up period. All variables which have been found to be mainly associated with AF recurrence after AF surgery were used as covariates (11, 12). Two-sided P values were calculated. All statistical analyses were performed using SPSS statistical software, version 21.0 (IBM Corp).

3. Results

3.1. Baseline and Clinical Outcomes

Out of 65 patients, 25 patients underwent biatrial cryoablative CMP-IV and 40 patients underwent surgical cryo-PVI for long-standing persistent AF. Patients’ mean age was 49.6 ± 10.6 years and female sex (67.7%) was predominant in our cohort. MVR alone and MV repair alone were performed in 23 patients (35.4%) and 9 patients (13.8%), respectively. The most concomitant surgery with MVR was tricuspid valve (TV) repair (28% in the CMP-IV and 20% in the PVI groups, P = 0.456). Other characteristics are summarized in Table 1.

Table 1. Baseline and Intraoperative Characteristics Based on the Study Groupa
Total (n = 65)CMP IV (n = 25)PVI (n = 40)P Value
Age, y49.6 ± 10.643.8 ± 9.953.2 ± 9.4< 0.001
Gender, female44 (67.7)17 (68)27 (67.5)0.967
AF duration, month12 (9 to 23)13 (9 to 32)11.5 (8.5 to 20.5)0.507
Prior histories
Diabetes mellitus5 (7.7)2 (8)3 (7.5)0.941
Hypertension8 (12.3)4 (16)4 (10)0.474
CVA7 (10.8)2 (8)5 (12.5)0.569
CAD9 (13.8)3 (12)6 (15)0.733
Digoxin consumption46 (70.8)18 (72)28 (70)0.863
Echocardiographic features
LA size, cm5.1 ± 1.15.2 ± 1.25 ± 1.10.472
LA clot5 (7.7)3 (12)2 (5)0.303
LVEF, %50 (45 to 55)50 (45 to 55)47 (45 to 50)0.131
AV insufficiency25 (38.5)8 (32)17 (42.5)0.397
AV stenosis4 (6.2)0 (0)4 (10)0.103
TV stenosis1 (1.5)0 (0)1 (2.5)0.426
TV regurgitation21 (32.3)7 (28)14 (35)0.557
MV stenosis53 (81.5)20 (80)33 (82.5)0.800
MV regurgitation36 (55.4)17 (68)19 (47.5)0.106
ASD2 (3.1)2 (8)0 (0)0.069
CPB time, minute120 (94 to 145)123 (95 to 150)118 (92 to 142.5)0.526
ACC time, minute81 (55 to 100)80 (55 to 98)83 (60 to 102)0.746
Concomitant cardiac surgery
MVR23 (35.4)8 (32)15 (37.5)0.652
MV repair9 (13.8)2 (8)7 (17.5)0.281
OMVC4 (6.2)1 (4)3 (7.5)1
MVR and TV repair15 (23.1)7 (28)8 (20)0.456
MVR and AVR11 (16.9)4 (16)7 (17.5)0.875
MVR and TV repair and AVR6 (9.2)2 (8)4 (10)0.786
MVR and AV repair3 (4.6)1 (4)2 (5)1
MVR and CABG3 (4.6)2 (8)1 (2.5)0554
MVR and LA clot removal5 (7.7)3 (12)2 (5)0.365
MVR and PFO closing3 (4.6)1 (4)2 (5)1

Abbreviations: AF, atrial fibrillation; ASD, atrial septal defect; AV, aortic valve; AVR, aortic valve replacement; CABG, coronary artery bypass graft; CMP, Cox-Maze procedure; CPB, cardiopulmonary bypass time; LA, left atrium; LVEF, left ventricular ejection fraction; MV, mitral valve; MVR, mitral valve replacement; OMVC, open mitral valve commissurotomy; PFO, patent foramen ovale; PVI, pulmonary vein isolation; TV, tricuspid valve.

aValues are expressed as mean ± SD, No. (%) or median (interquartile ranges).

The amount of hospital stay was not significantly different between the groups (13 [9 to 16] in the CMP-IV and 12.5 [9 to 17.5] days in the PVI, P = 0.962). Patients were followed for a median of 16 months (ranging from 3 to 60 months) and no difference was observed between the groups, P = 0.332 (12 [9 to 24] versus 16 [8 to 29] months; Table 2).

Table 2. Clinical Outcomes During Short-Term and Long-Term Follow-Up in the Study Groupsa
CMP-IV (n = 25)PVI (n = 40)P Value
ICU stay, d2 (1 to 2)2 (1 to 2.5)0.714
Hospital stay, d13 (9 to 16)12.5 (9 to 17.5)0.962
Complications0.297
Bleeding1 (4)2 (5)
Malfunction1 (4)1 (2.5)
Drainage3 (12)1 (2.5)
Others04 (10)
Follow-up duration, month12 (9 to 24)16 (8 to 29)0.332

Abbreviations: CMP, Cox-Maze procedure; ICU, intensive care unit; PVI, pulmonary vein isolation.

aValues are expressed as mean ± SD, No. (%) or median (interquartile ranges).

The late follow-up was available in 58 patients (89.2%). The rate of freedom from AF at different intervals, including first day of intensive care unit (ICU) admission, first day of ward admission, at discharge time, 1 month postoperatively, and at late follow-up was not significantly different between the intervention groups (Figure 2). No cases of in-hospital mortality, thromboembolic events, and infective endocarditis were developed. No permanent pace-maker implantation was necessary in our cohort. Mortality and thromboembolic events at late follow-up were not also detected in these patients, although we could not followed up 11% patients at late period.

Figure 2. Freedom From AF at Follow-Up Intervals Based on the Study Groups
Freedom From AF at Follow-Up Intervals Based on the Study Groups

None of the comparisons were significantly different between the intervention groups.

ROC curve analysis was used to detect a cut-off pint for preoperative LA size differentiating the patients with AF development at late follow-up. LA size of 4.5 cm discriminated AF, regardless of the study intervention, with a sensitivity of 89% and a specificity of 45% (area under the ROC curve = 0.733, 95% confidence interval [CI] = 0.602 - 0.863, P = 0.005; Figure 3).

Diagnostic Accuracy of Preoperative LA Size to Detect AF at Late Follow-Up
Figure 3. Diagnostic Accuracy of Preoperative LA Size to Detect AF at Late Follow-Up

3.2. ROC Curve Analysis

Moreover, based on the cut-off value of 4.5 cm for preoperative LA size, all patients were also divided into two groups (LA ≤ 4.5 [n = 20] and LA > 4.5 cm [n = 45]). There were no significant differences regarding the baseline and intraoperative characteristics between these groups except for AF duration that was significantly greater in the LA > 4.5 group (Table 3). When the rate of freedom from AF during follow-up was compared, the numbers of patients with sinus rhythm at 1-month and late follow-ups were significantly higher in LA > 4.5 group compared with the LA ≤ 4.5 group (Figure 4).

Table 3. Baseline Characteristics and Follow-Up Outcomes Based on the LA Size Groupsa
LA ≤ 4.5 (n = 20)LA > 4.5 (n = 45)P Value
Age, y49.5 ± 9.549.6 ± 11.10.966
Gender, female13 (65)31 (68.9)0.757
Study groups (CMP IV/PVI)5/15 (25/75)20/25 (44.4/55.6)0.137
AF duration, month9 (7 to 17)13 (9 to 38)0.035
Prior histories
Diabetes mellitus1 (5)4 (8.9)1
Hypertension1 (5)7 (15.6)0.232
Cerebrovascular events2 (10)5 (11.1)1
Coronary artery disease1 (5)8 (17.8)0.169
Digoxin consumption16 (80)30 (66.7)0.275
Beta blocker use 10 (50)14 (31)0.145
Echocardiographic features
LA size, mm3.9 ± 0.45.6 ± 0.9< 0.001
LA clot3 (15)2 (4.4)0.165
LVEF, %50 (45 to 55)50 (45 to 55)0.630
AV insufficiency8 (40)17 (37.8)0.865
AV stenosis04 (8.9)0.303
TV stenosis01 (2.2)1
TV regurgitation5 (25)16 (35.6)0.401
MV stenosis14 (70)39 (86.7)0.110
MV regurgitation10 (50)26 (57.8)0.560
ASD2 (10)00.091
Inotropic use2 (10)8 (17.8)0.422
CPB time, minute125.5 (91.5 to 142)117 (94 to 147)0.086
Aortic cross-clamp time, minute91 (55 to 105.5)80 (56 to 97)0.501
Concomitant cardiac surgery
MVR6 (30)17 (37.8)0.545
MV repair5 (255)4 (8.9)0.120
OMVC2 (10)2 (4.4)0.581
MVR and TV repair1 (5)14 (31.1)0.021
MVR and AVR2 (10)9 (20)0.321
MVR and TV repair and AVR06 (13.3)0.087
MVR and AV repair1 (5)2 (4.4)1
MVR and CABG03 (6.7)0.547
MVR and LA clot removal3 (15)2 (4.4)0.165
MVR and PFO closing1 (5)2 (4.4)1
ICU stay, day2 (1 to 2.5)2 (1 to 2)0.155
Hospital stay, day14 (9 to 16)12 (9 to 16)0.214
Complications0.348
Bleeding1 (5)2 (4.4)
Malfunction1 (5)1 (2.2)
Drainage1 (5)3 (6.7)
Others3 (15)1 (2.2)
Follow-up duration, month20 (12.5 to 29.5)12 (8 to 24)0.325

Abbreviations: ACC, aortic cross clamp time; AF, atrial fibrillation; ASD, atrial septal defect; AV, aortic valve; AVR, aortic valve replacement; CABG, coronary artery bypass graft; CMP, Cox-Maze procedure; CPB, cardiopulmonary bypass time; LA, left atrium; LVEF, left ventricular ejection fraction; MV, mitral valve; MVR, mitral valve replacement; OMVC, open mitral valve commissurotomy; PFO, patent foramen ovale; PVI, pulmonary vein isolation; TV, tricuspid valve.

aValues are expressed as mean ± SD, No. (%) or median (interquartile ranges).

Figure 4. Freedom From AF at Follow-Up Intervals Based on the LA Size Groups
Freedom From AF at Follow-Up Intervals Based on the LA Size Groups

The only significant differences were observed at 1 month and late follow-up periods.

3.3. Multivariate Analysis

In Cox regression analysis, covariates included age, gender, the study intervention groups, preoperative LA size, AF duration, and the number of concomitant surgeries (one, two, and three concomitant surgeries). The predictors of AF at late follow-up were the preoperative LA size (Hazard ratio [HR] 1.962, 95% CI 1.175 - 3.276, P = 0.010) and AF duration (HR 1.028, 95% CI 1.002 - 1.054, P = 0.032) (Table 4).

Table 4. Cox regression Analysis Identifying the Predictors of AF at Long-Term Follow-Up
HR95% CIP Value
Age1.0440.986 - 1.1040.138
Gendera0.8020.286 - 2.2460.674
Study groupb0.3400.114 - 1.0210.054
AF duration1.0281.002 - 1.0540.032
LA size1.9621.175 - 3.2760.010
Number of concomitant surgeriesc
One surgery--0.331
Two surgeries0.5920.179 - 1.9550.390
Three surgeries0.3150.068 - 1.4600.140

Abbreviations: AF, atrial fibrillation; CI, confidence interval; HR, hazard ratio; LA, left atrium.

aThe reference value was male gender.

bThe reference value was the PVI group.

cThe reference value was patients undergoing one surgery.

4. Discussion

In this study we showed that the rate of freedom from AF at late follow-up was similar for both the cryoablative biatrial CMP-IV and the surgical cryo-PVI in patients with rheumatic MV disease associated with long-standing persistent AF undergoing MVR or MV repair with or without concomitant cardiac surgeries. Moreover, a cut-off point of 4.5 cm for the preoperative LA size discriminated late AF with sensitivity and specificity of 89% and 45%, respectively. The preoperative LA size measured by echocardiography and the duration of AF were also found to be the main predictors of AF at late follow-up.

Among various surgical approaches for treating AF, only the CMP has been proved to be the gold standard for surgical treatment of AF. Regarding the application of AF ablation concomitant with MV surgeries, a recent meta-analysis of 9 randomized studies has found that AF ablation along with MV surgeries compared to alone surgery was associated with an increased freedom from AF and decreases in need for permanent pacemaker implantation and thromboembolism events (13). In contrast, Gillinov et al. (14) have demonstrated that freedom from AF was significantly higher in ablation group compared to alone surgery group, although the need for permanent pacemaker implantation was greater in ablation group. On the other hand, none of the patients in our cohort required permanent pacemaker implantation. We think that underlying arrhythmia such as sick sinus syndrome should be investigated in such groups before anti-arrhythmic surgeries. Moreover, the absence of need for pacemaker implantation in our study may be caused by a relative small sample size and the lack of sick sinus syndrome in our patients.

In our center, the only energy source available was cryothermy that has been previously demonstrated to have a success rate of 65% at 1-year follow-up in both the CMP and PVI (15). Ad et al. (16) reported excellent results with an early success rate of 98% and mortality rate of 3.7% by using cryoablative CMP. In a series of cryoablative PVI with concomitant valvular surgeries, the rates of sinus rhythm were 78% and 69% at postoperative time and long-term follow-up, respectively (17). Furthermore, in a recent large-scale randomized study, the rate of sinus rhythm at follow-up was similar for patients undergoing cryoablative PVI or biatrial CMP (14). Despite studies for approving cryothermy source for AF ablation and showing the similar results in the settings of PVI or CMP, further studies are deemed indicated to further clarify the difference between the cryoablative CMP-IV and surgical cryo-PVI during concomitant valvular surgeries.

All patients in our study had rheumatic mitral valve disease that underwent valvular surgeries along with cryosurgical ablations. Although CMP has been an efficient surgical treatment, two studies have reported that early surgical outcomes for AF associated with MV disease, especially rheumatic MV disease, is less effective (18, 19). It seems that the poor CMP outcomes in the setting of rheumatic MV surgery might be attributed to the RHD inflammation and long duration of AF 18. In addition, it has been postulated that progressively decreasing freedom from AF in such patients can derive from progressive rheumatic changes to the atrial wall or degeneration of atrial tissue resulting from pressure and volume overloading which occurs in valvular heart disease (20). Given these points and our findings, although the rate of freedom from AF decreased at late follow-up, but the success rate in our cohort was acceptable and longer follow-up can be more conclusive in this issue.

The preoperative LA size, AF duration, and patients’ age have been found to be the main predictors of success rate at surgical ablation (11, 12, 21). However, Ad et al. (21) showed that the predictors of sinus rhythm at follow-up period were different in mid- and long-term follow-up. They concluded that we need follow-up longer than 5 years to determine the main predictors of success rate in the surgical ablation of AF. In the present study, in line with previous studies, we showed that the main predictors of AF rhythm at late follow-up were the preoperative LA size and duration of AF, although the cryoablation technique and PVI versus the CMP-IV, did not predict procedure failure. Moreover, we found that the cut-off value of 4.5 cm for LA size discriminated AF during long-term period. We did not equalize the preoperative LA size in the study groups; however, based on subgroup analysis the number of patients with LA > 4.5 cm was comparable between the study groups. According to Sunderland et al. (22) there is no evidence to the contrary that LA diameter less than 4.3 cm is associated with complete CMP success, and the preoperative LA diameter greater than 6 cm has 100% sensitivity to discriminate CMP failure. However, in our cohort, two patients with preoperative LA size of < 4.3 cm had AF at late follow-up period and no patients with LA size of > 6 cm had procedure failure too.

4.1. Study Limitations

This study has its limitations. First, it was small cohort of non-randomized patients. Second, the surgically created ablation scheme did not validated with electroanatomic mapping during the study period and no histologic study performed to identify ablation size or lesion depth.

4.2. Conclusions

N2O-based cryoablative procedures for persistent or long-standing persistent AF are safe, efficacious, and cost-effective at restoring sinus rhythm in the setting of rheumatic MV surgery combined with or without other cardiac surgeries, regardless of the surgical cryo-PVI or cryoablative CMP-IV. However, these cryosurgical ablations were less effective in patients with larger preoperative LA size.

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